Aim

To assess the effectiveness of pirfenidone as a concomitant therapy with surgery in the treatment of severe facial trauma in pediatrics.

Methods

  • A 16-month-old female patient who suffered a severe attack in the midface area was managed with surgery/ PFD combination.
  • Pirfenidone gel 8% was applied t.i.d. for 1 year to improve scar progress and epithelization.

Results

Surgery/PFD combination offered a good complementary therapy downregulating inflammatory activity, improving blood supply, and activating cytokine modulation and collagen synthesis/biosynthesis (scar control)

No side effects were reported during PFD administration.

Conclusion

Surgery/PFD management for severe facial dog bites represents a safe and effective therapeutic option to protect and improve a patient's quality of life, minimizing long-term sequels.